Ian Day, MA,MB,BChir,PhD,FRCPath

Professor of Molecular and Genetic Epidemiology

Bristol Genetic Epidemiology Laboratories,
School of Social and Community Medicine,
Oakfield House, Oakfield Grove, Bristol, BS8 2BN

I qualified from the University of Oxford in 1980 with First Class Honours in Physiological Sciences and gained my medical degree with distinction from the University of Cambridge in 1982.  My PhD, undertaken on an MRC Training Fellowship in the Department of Clinical Biochemistry in Cambridge, was in the protein chemistry, immunochemistry and molecular cloning of the protein PGP9.5 and its gene (UCHL1). I accredited in medical biochemistry and completed the MRCPath (in Chemical Pathology) in 1992. From 1992-1995 I held a BHF Intermediate Fellowship at UCLMS and from 1996-2000 was a Lister Institute Fellow. From 1997-2006 I was Professor of Human Genetics at the University of Southampton. Since 1993 much of my research has been in the genetics of cardiovascular diseases and risk factors.

To 2009, I have published over 150 original papers, 50 reviews and chapters, and edited 4 books. I have had almost continuous UK research funding from MRC since 1984 and BHF since 1992 and numerous other funding support ranging from building, JREI, SRIF and other infrastructure awards, to a range of focused project grants. I was head of the Division of Human Genetics (~150 staff and students) in Southampton Medical School for 6 years, where I also ran a group of 15-25 researchers for 9 years. I was head of the postgraduate school of Southampton Medical School for 3 years. I have also had experience of patents, IP and a small spin-out company. I have taught medical biochemistry and genetics at BM, BSc, MSc and PhD/MD levels. I served on BHF project grants panel for 4 years, am a member of MRC College of Experts, have served on UK Foresight panel and EU funding planning panels, am a member of numerous genetics advisory committees and also the MRC DNA Banking Network Oversight Committee, I am reviews editor for Human Genetics and on the editorial boards of Human Mutation, Frontiers in Genetics, International Journal of Molecular Epidemiology and Genetics and Clinical Laboratory. For the past two decades I have been fully and continuously engaged with clinical, laboratory and statistical aspects of genetic epidemiological population and family research studies and recognise the syntheses of systems biology and hypothesis driven research and of combining technologies effectively into biomedical and translational research.

Since 2007 I have been Deputy Director of the MRC Centre (Causal Analysis in Translational Epidemiology) at the University of Bristol. In addition to Bristol Genetic Epidemiology Laboratories, I also lead (since 2009) an MRC funded doctoral training programme in Systems Biomedicine (mathematical, statistical and computational approaches to medical research). I am a visiting professor at King Saud University, Riyadh, Saudi Arabia (invited 2010). I have been an external examiner for an MSc in Molecular Diagnostics (University of Nottingham, 2007-2009), for Final MB Clinical Pathology (University of Cambridge, 2007-2010) and for MRCPath (Genetics, 1997-present).


Peer reviewed publications in PubMed. Please wait for the up-to-date list to load from PubMed, or go direct to the PubMed results.

Chapters and Reviews
  • Day, I.N.M., Spanakis, E., Hinks, L.J., Voropanov A., Chen, X., O’Dell, S.D. (2001) Microplate array diagonal gel electrophoresis (MADGE) methodologies: the first five years. Chapter 7 in Day, I.N.M. (editor) Book ‘Molecular Genetic Epidemiology – A Laboratory Perspective’ Cambridge, Springer-Verlag, Berlin, Heidelberg, New York 2001, pp 157-181.  (Cat. CR35)
  • *IN.M. Day, M.A.Al-Dahmesh#, K.K. Alharbi#,  X.Chen#, R.H.Ganderton#, T.R. Gaunt#, L.J. Hinks#, S.D. O’Dell1#, E. Spanakis2#, P.J.R. Day3, M.A. Suchard4 , B.B. Zhang5, M.R. James6 Electrophoresis in microplate formats. Chapter in Ye, S and Day, I.N.M (eds) Book ‘Microarrays and microplates’ BIOS Press, Oxford, UK, 2003 (Cat. CR44, pdf)

  • MeltMADGE: economical very high throughput mutation scanning using thermal ramp electrophoresis in conjunction with MADGE (microplate array) gels *I.N.M. Day, M.A.Al-Dahmesh, L. Haddad1, K.K. Al-Harbi, X.Chen, H. Rassoulian2, S.E. Humphries3, E. Spanakis4, D. Eccles (Chapter 9 (and protocols chapter 35) in Mutation Detection, Wiley, eds GR Taylor, INM Day) 2005 (Cat.CR41)

  • *Ian N M Day,  Rosalind H Ganderton, Xiao-he Chen, Tom R Gaunt  Microplate Array Diagonal Gel Electrophoresis For SNP And Microsatellite Genotyping And For Mutation Scanning. in  Encyclopedia of Diagnostic Genomics and Proteomics (EDGP) edited by Jürgen Fuchs and Maurizio Podda pp.836-841 2005 Marcel Dekker, Inc (Cat.CR42)
  • Experience applying LightTyper methodology to human SNPs relevant to growth and cardiovascular risk. *Tom R Gaunt, Lesley J Hinks, Mikkel B Christensen, Matthew Kiessling, Ian N. M. Day Chapter 5 in Genetic Variance Detection: technologies for pharmacogenomics (ed Karl Hecker) DNA Press pp 131-144 (Cat. CR45)
  • MADGE-based technologies for identification of unknown mutations at the population level. Matt  Smith1, Khalid K. Alharbi1, Mohammed A Aldahmesh, Gabriella Pante-de-Sousa1,2, Guangwei Hou, Xiao-he Chen1, Diana M. Eccles, Keith R.Fox3, Ian N. M. Day1 Chapter 6 in Genetic Variance Detection: technologies for pharmacogenomics (ed Karl Hecker) DNA Press pp 145-162(Cat. CR46)
  • Genetic endocrinology of the metabolic syndrome:networks of genotype-determined feedback loop setpoints Santiago Rodríguez 1, Tom R Gaunt 1, Mohammad Reza Abdollahi 2, Sabine Sonnenberg 1 and Ian N M Day Nova Book, accepted -7-06 (Cat.CR49)
  • Day, I.N.M.  Use of genetic profiling in cardiovascular disease. Key Opinion (Editorial) for InCirculation.net. 2003 (CR43, html)
  • Day, Ian; Rodriguez, Santiago; Kralovicova, Jana; Wood, Peter; Vorechovsky, Igor; Gaunt, Tom. Questioning INS VNTR role in obesity and diabetes:subclasses tag IGF2-TH-INS haplotypes;and -23HphI as a STEP(splicing and translation efficiency polymorphism) Physiological Genomics (accepted 4-7-06) (CR50)
  • Dr. Santiago Rodríguez, Dr. Tom R Gaunt, Shuwen Huang, Dr. Mohammad R. Abdollahi, Dr. Khalid Al-Harbi, Dr. Xiao-he Chen and Professor Ian N. M. Day. Genomic applications of Microplate-Array Diagonal-Gel Electrophoresis (MADGE): Approaches for SNPs, microsatellites, RNA expression and unknown mutations.  BIOforum Europe 01/2005, pp 42–43, GIT VERLAG GmbH & Co. KG, Darmstadt, Germany, www.gitverlag.com/go/bioint (Cat. CR47) . Selected for republication in BIOforum Europe Highlights issue for 2006, 01/2006, pp 52-53.
  • *Tom R Gaunt, Lesley J Hinks, Mikkel B Christensen, Matthew Kiessling, Ian N. M. Day. Uses of the LightTyper in human genotype analysis: SNPs, microhaplotypes and large insertion/deletions. Biochemica 2005, issue 2 pages 04-06 http://www.roche-applied-science.com/PROD_INF/BIOCHEMI/no2_05/pdf/p04.pdf (CR48) reprinted in New Drugs, http://www.new-drugs.com/index.html, xx/05
  • *Tom R Gaunt, Lesley J Hinks, Mikkel B Christensen, Matthew Kiessling, Ian N. M. Day. Uses of the LightTyper in human genotype analysis: SNPs, microhaplotypes and large insertion/deletions.. Reprint of CR48 in New Drugs.  http://www.new-drugs.com/index.html
  • Day, I.N.M., Gu D, Ganderton RH, Spanakis, E., Ye, S (2001).  Epidemiology and the genetic basis of disease.  Int. J. Epidemiol. 30: 661-667
  • Day INM (2003) Monogenic Hypercholesterolemia: Genetics. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 4, article A5940 pp. 69-74. London: Nature Publishing Group. (Cat. CR39). Now integrated (2006) following buy of EHG by John Wiley & Sons Ltd, Chichester UK, into Encyclopedia of Life Sciences (ELS) Online.
  • 1Baiping Zhang, 2Kaare Fugleholm, 1Lorna B Day, 1Shu Ye, 2Roy O Weller, 1Ian N M Day* (2003) Molecular pathogenesis  of  subarachnoid haemorrhage.  Int J Biochem Cell Biol (submitted by ID 10/02, minor revisions requested and completed 6/12/02, accepted, proofs 02/03, in press) 35, 1341-1360 (Cat. CR37, pdf)
  • Day, I.N.M.  (2004) In what situations is genetic testing currently useful for management of individual patients to prevent or treat cardiovascular disease?  Dialogues in Cardiovascular Medicine 9(1) 23-29  (Cat. CR38)
  • Ian N M Day, Khalid K Alharbi, Matt Smith, Mohammed A. Aldahmesh, Xiao-he Chen, Andrew J. Lotery, 1Gabriella Pante-de-Sousa, Guangwei Hou, Shu Ye, Diana Eccles, Nicholas C P Cross, 2Keith R Fox, Santiago Rodriguez (2004) Paucimorphic alleles versus polymorphic alleles and rare mutations in disease causation: theory, observation and detection Current Genomics, 5, 431-438  (Cat. CR40)
Books edited
  • Taylor, G.R. and, Day, I.N.M. (eds) Mutation Detection Wiley Press (2005)
  • Ye, S and Day, I.N.M. (eds) Book ‘Microarrays and microplates: applications in the biosciences’ BIOS Press, Oxford, UK 2003
  • Day, I.N.M. (editor) Book ‘Molecular Genetic Epidemiology – A Laboratory Perspective’ Cambridge, Springer-Verlag, Berlin, Heidelberg, New York 2001 (Cat. CR24)
  • Day, I.N.M.  (editor)  'Genetics of common disease: future therapeutic and diagnostic opportunities,' BIOS Scientific Publishers, Oxford, UK. 1997.(Cat. CR10)